The overarching theme of the Santangelo lab is the spatial biology of RNA viruses and RNA regulation. So what is spatial biology - it is the study of biology in three dimensions - and we develop advanced imaging tools to acheive this goal. We focus our tools on the spatial biology of HIV/SIV and human respiratory synctial virus (leading cause of bronchiolitis and pneumonia in babies), and the aberrant regulation of messenger RNA during inflammation, viral infections and cancer pathogenesis. We have developed both single molecule methods and whole body imaging methods in order to work towards our goals.
Philip Santangelo wants to build a toolbox of mRNA drugs to activate or shut off specific genes to help the immune system fight cancer and other disorders.