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Machelle Pardue
Machelle Pardue
Professor
UAW 4104
404.385.3666
Research Interests:

Neuroprotective treatments, Retinal mechanisms of refractive development, Diabetic retinopathy

Dr. Pardue’s research interests can be divided into three main topics:

Neuroprotective treatments
Originating with biocompatibility studies with a subretinal prosthetic, Dr. Pardue has been investigating the neuroprotective effects of subretinal electrical stimulation (SES) on the retina using electrophysiological, histological, and molecular techniques. This work has shown that low level electrical current preserves photoreceptor function and structure. This preservation is associated with the selective and sustained upregulation of fibroblast growth factor beta (FGF2). Currently, her laboratory is exploring cellular and molecular mechanisms of this neuroprotective response as well as determining which retinal diseases benefit from SES.

Her laboratory also has been involved in testing other neuroprotective agents with anti-apoptotic properties, such as the bile acid, tauroursodeoxycholic acid (TUDCA), and other proprietary formulas. These studies are designed to develop neuroprotective treatments for retinal degenerative diseases that could slow the progression of vision loss.

Retinal mechanisms of refractive development
Combining her knowledge of the retina, transgenic mouse models, and optical aspects of the eye, Dr. Pardue is investigating how retinal defocus is detected by the retina and translated into a signaling pathway that drives refractive development. By exploiting transgenic mouse models, the influence of specific retinal cells and pathways can be isolated to determine refractive development, particularly myopia, under normal and abnormal visual conditions. This work is aimed at furthering our knowledge of basic retinal physiology, refractive development and refractive errors.

Diabetic retinopathy
Diabetic retinopathy, one of leading causes of vision loss, is currently only detected in late stages of the disease. Dr. Pardue’s research on diabetic retinopathy is focused on finding non-invasive predictive markers of this disease. Her laboratory is combining information from electrophysiological, imaging, immunohistochemical, and molecular techniques to build a complete understanding of the pathophysiology of neuronal and vascular changes with diabetic retinopathy. These studies focus on following diabetic animal models longitudinally to reveal changes that predict vision loss. With this knowledge, predictive, non-invasive imaging and electrophysiologic changes will be further examined and translated to clinical studies. The goal is to detect diabetic retinopathy before vision loss occurs, thus providing an opportunity for increased glycemic control and/or other pharmacological treatments.

Publications:
  

Map of Coulter Department of Biomedical Engineering at Georgia Tech and Emory University

BME @ Emory

Coulter Department of Biomedical Engineering
Georgia Institute of Technology &
Emory University School of Medicine

BME @ GT:
313 Ferst Drive, Room 2127 Atlanta, GA 30332
Phone: 404.385.0124 :: Fax: 404.894.4243

TEP @ GT:
387 Technology Circle NW Atlanta, GA 30313
Phone: 404.385.0124 :: Fax: 404.894.4243

BME @ Emory:
1760 Haygood Dr, Ste W 200 Atlanta, GA
30322-4250
Phone: 404.727.9874 :: Fax: 404.727.9873