"From Mechanical Forces to Tissue Straining – How to Employ Biophysical Cues to Guide Regeneration"
Univ.-Prof. Dr.-Ing. Georg Duda
Julius Wolff Insitute and Berlin Institute of Health Center for Regenerative Therapies (BCRT)
Charité - Universitätsmedizin Berlin
Wyss Institute for Biologically Inspired Engineering at Harvard University
Conceptually, our research aims at understanding endogenous cascades of tissue formation, cytokine signaling and cellular self-organization especially in bone. Mechanical straining and adaptation due to mechanical cues plays a central role in all these tissues. The aim of our work is to understand the mechano-biological cues of regeneration and adaptation and how they can be employed to enable healing even in tissues with impaired regenerative capacity such as muscle, cartilage or tendon. All approaches are motivated by clinical challenges, are based on in vivo patient measurements, employ basic research principles and aim at being translated into daily clinical routine. Examples of translation include innovative concepts for joint replacement procedures, angle stable fixation of implants or cell therapies for immune-modulation to empower tissue regeneration.
Georg Duda is director of the Julius Wolff Insitute, co-director of the Berlin Center Regenerative Therapies and Professor of Biomechanics and Musculoskeletal Regeneration at the Charité – Humboldt University of Berlin and Free University of Berlin and an Associated Faculty Member at the Wyss Institute for Biologically Inspired Engineering at Harvard University. He received his Ph.D. degree in Mechanical Engineering from the Technical University of Hamburg-Harburg in 1996. After stays at Mayo Clinic, Johns Hopkins University, Technical University Hamburg-Harburg and University of Ulm, he moved to Berlin to initiate a regenerative research focus in musculoskeletal surgery. He initiated a clinician scientist program and chairs the graduate school Berlin-Brandenburg School for Regenerative Therapies.
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