While biomechanics research spans from the cell to the organ level in fluid and solid mechanics, and includes experimental and computational approaches encompassing a wide range of basic and applied projects, the work in the cardiovascular area is particularly strong. Studies on the fluid dynamics of blood flow are being conducted using in vitro models, in vivo experimentation, and computational methods. Specific applications include the fluid mechanics of the heart and large vessels, coronary arteries, vascular grafts, and the abdominal aorta and peripheral vasculature. Research in fluid dynamics associated with mechanical heart valves, new bioprosthetic designs, and polymeric trileaflet valve prostheses is internationally recognized. Cardiovascular solid mechanics work addresses mechanical properties and stresses in diseased arterial cross sections, and examines the role of mechanical factors in the disruption of atherosclerotic plaques.

On the applied side, the effects of cryopreservation on mechanical properties of arteries and veins are being determined to evaluate the potential for cryopreserved tissues to replace injured or diseased vessels as allografts.