Recent Publications

2009 Publications

78. Wu T., Lin J., Cruz M. A., Dong J., Zhu C., 2009, "Force-induced cleavage of single VWF A1A2A3-tridomains by ADAMTS-13", Blood. Full Text in PDF

77. Auton M., Sedlak E., Marek J., Wu T., Zhu C., and Cruz M.A., 2009, “ Changes in Thermodynamic Stability of von Willebrand Factor Differentially Affect the Force-Dependent Binding to Platelet GPIbt ”, Biophys J., 97:618-627. Full Text in PDF

76. Kong F., García A.J., Mould A.P., Humphries M.J. and Zhu C., 2009, “Demonstration of catch bonds between an integrin and its ligand”, J. Cell Biol., 185:1275-1284. Full Text in PDF

Supplementary Materials

2008 Publications

73. Hung Y., Zarnitsyna V., Zhang Y., Zhu C., and Wu C.F.J. 2008, "Binary Time Series Modeling With Application to Adhesion Frequency Experiments", J. Am. Stat. Asso. 103 (483): 1248-1259. Full Text in PDF

72. Chen W., Zarnitsyna V. I., Sarangapani K. K., Huang J., Zhu C., 2008 , " Measuring Receptor-ligand Binding Kinetics on Cell Surfaces: From Adhesion Frequency to Thermal Fluctuation Methods", Cell. Mol. Bioeng., DOI:10.1007/s12195-008-0024-8. Full Text in PDF

71. Wasserman H. A., Beal C. D., Zhang Y., Jiang N., Zhu C., and Evavold B. D., 2008, " MHC Variant Peptide-Mediated Anergy of Encephalitogenic T Cells Requires SHP-1", J. Immunol., 181:6843-6849. Full Text in PDF

70. Yago T., Lou J., Wu T., Yang J., Miner J. J., Coburn L., Lopez J. A., Cruz M. A., Dong J.-F., McIntire L. V., McEver R. P., and Zhu C., 2008, "Platelet Glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF", J. Clin. Invest., 118(9):3195-3207. Full Text in PDF

69. Lou J., and Zhu C., 2008, “Flow induces loop-to-beta-hairpin transition on the beta-switch of platelet Glycoprotein Ibalpha", Proc. Natl. Acad. Sci. U.S.A., 105:13847-13852. Full Text in PDF

68. Chen Z., Lou J., Zhu C., and Schulten K., 2008, "Flow-Induced Structural Transition in the beta-switch Region of Glycoprotein Ib", Biophys. J., 95:1303-1313. Full Text in PDF

67. Wright A., Li Y.-H., Zhu C., 2008, "Integrin Dependence of Calu-1 Cell Motility on Endothelial Extracellular Matrix Proteins", Ann. Biomed. Eng., 36(6):970-979. Full Text in PDF

66. Wright A., Li Y.-H., Zhu C., 2008, "The Differential Effect of Endothelial Cell Factors on In Vitro Motility of Malignant and Non-malignant Cell", Ann. Biomed. Eng., 36(6) 958-969. Full Text in PDF

65. Tolentino T. P., Wu J., Zarnitsyna V. I., Fang Y., Dustin M. L., Zhu C., 2008, " Measuring Diffusion and Binding Kinetics by Contact Area FRAP”, Biophys J., 95:920-930. Full Text in PDF

64. Wu J., Fang Y., Zarnitsyna V. I., Tolentino T. P., Dustin M. L., Zhu C., 2008, "A Coupled Diffusion-Kinetics Model for Analysis of Contact Area FRAP Experiment", Biophys J., 95:910-919. Full Text in PDF

63. Zhu C., Yago T., Lou J., Zarnitsyna V.I., and McEver R. P., 2008, "Mechanisms for Flow-Enhanced Cell Adhesion", Ann. Biomed. eng., 36: 604-621. Full Text in PDF

62. Klopocki A. G., Yago T., Mehta P., Yang J., Wu T., Leppanen A., Bovin N. V., Cummings R. D., Zhu C., and McEver R. P.,2008, "Replacing a lectin-domain residue in L-selectin enhances binding to P-selectin Glycoprotein ligand-1 but not to 6-sulfo-sialyl Lewis X." J. Biol. Chem., 283(17):11493-500. Full Text in PDF

61. Nath S. K., Han S., Kim-Howard X., Kelly J. A., Viswanathan P., Gilkeson G. S., Chen W., Zhu C., McEver R. P., Kimberly R. P., Alarcon-Riquelme M. E., Vyse T. J., Li Q.-Z., Wakeland E. K., Merrill J. T., James J. A., Kaufman K. M., Guthridge J. M. and Harley J.B., 2008, "A nonsynonymous functional variant in integrin-alphaM (encoded by ITGAM) is associated with systemic lupus erythematosus", Nature Genet.,40(2), 152-4. Full Text in PDF Supporting Materials

60. Chen W., Evans A. E., McEver R.P., Zhu C., 2008, "Monitoring receptor-ligand interactions between surfaces by thermal fluctuations", Biophy. J., 94, 694-701. Full Text in PDF

59. Chien Y.-H., Jiang N., Li F., Zhang F., Zhu C., and Leckband D., 2008, "Two-stage cadherin kinetics require multiple extracellular domains but not the cytoplasmic region", J. Biol. Chem.,283, NO.4, pp.1848-1856 Full Text in PDF

2007 Publications

58. Huang J., Edwards L. J., Evavold B. D., Zhu C., 2007, "Kinetics of MHC-CD8 Interaction at the T Cell Membrane", J. Immunol., 179, 7653-7662 Full Text in PDF

57. McEver R. P., Zhu C., 2007, “A catch to integrin activation”, Nat. Immunol., 8, 1035-1037. Full Text in PDF

56. Zarnitsyna V. I., Huang J., Zhang F., Chien Y.-H., Leckband D., Zhu C., 2007, "From the Cover: Memory in receptor-ligand mediated cell adhesion", Proc. Natl. Acad. Sci. USA., 104, 18037-18042. Full Text in PDF

Online movie: Movie

55. Lou J., Yago T., McEver R. P. and Zhu C., 2007, "The Sliding-Rebinding Mechanism for Catch bond", Jap. J. Appl. Phys. 46, 5528-5535 Full Text in PDF

54. Torun H., Sutanto J., Sarangapani K. K., Joseph P., Degertekin F. L., and Zhu C., 2007, “A micromachined membrane-based active probe for biomolecular mechanics measurement", Nanotechnology, 18:165303 Full Text in PDF

53. Li P., Jiang N., Nagarajan S., Wohlhueter R., Selvaraj P., and Zhu C., 2007, “Affinity and kinetics analysis of Fcgamma receptor IIIa (CD16a) binding to IgG ligands ”, J Biol Chem, 282:6210-6221 Full Text in PDF

52. Lou J., and Zhu C., 2007, "A structure-based sliding-rebinding mechanism for catch bonds”, Biophys J., 92:1471-85 Full Text in PDF

51. Yago T., Zarnitsyna V.I., Klopocki A.G., McEver R.P., and Zhu C., 2007, "Transport governs flow-enhanced cell tethering through L-selectin at threshold shear", Biophys J., 92:330-42 Full Text in PDF

2006 Publications

50. Lou J.,Yago T., Klopocki A. G., Metha P., Chen W., Zarnitsyna V. I., Bovin N. V.,Zhu C., and McEver R. P., 2006, “Flow-enhanced adhesion regulated by a selectin interdomain hinge", J. Cell Biol., 174:1107-1117. Full Text in PDF

49. Dustin M.L., Zhu C., 2006, "T cells like a firm molecular handshake", Proc. Natl. Acad. Sci. USA., 103:4335-4336. Full Text in PDF

48. Long M., Chen J., Jiang N., Selvaraj P., McEver R.P., and Zhu C., 2006, "Probabilistic Modeling of Rosette Formation", Biophy.J., 91:352-363 Full Text in PDF

47. Lu S, Ye Z,Zhu C, and Long M, "Quantifying the effects of contact duration, loading rate, and approachvelocity on P-selectin-PSGL-1 interactions using AFM,"Polymer, 47:2539-2547, Full Text in PDF

46. Marshall B. T., Sarangapani K. K., Wu J., Lawrence M., McEver R.P. and Zhu C., 2006, "Measuring Molecular Elasticity by Atomic Force Microscope Cantilever Fluctuations", Biophys.J.90:681-692 Full Text in PDF

2005 Publications

45. Zhu C., McEver R.P., 2005, "Catch Bonds: Physical Models and Biological Functions", Molecular and Cellular Biomechanics, 2005 2(3):91-104. Full Text in PDF

44. Zhu C., Lou J., McEver R.P., 2005, "Catch Bonds: Physical Models, Structural Bases, Biological Functions, and Rheological Relevance", Biorheology, 2005, 42: 443-462Full Text in PDF

43. Zhang F., Marcus W.D., Goyal N.F., Selvaraj P., Springer T.A., Zhu C., 2005, "Two-Dimensional Kinetics Regulation of α_Lβ₂-ICAM-1 Interaction by Conformational Changes of the α_L Inserted Domain", J. Biol. Chem., 280:42207-42218 Full Text in PDF

42. Wu J. H., Fang Y., Yang D., and Zhu C., 2005, "Thermo-mechanical Responses of a Surface-coupled AFM Cantilever," Journal of Biomechanical Engineering by ASME, Dec.2005, 127:1208-1215 Full Text in PDF

41. Marshall B. T., Sarangapani K. K., Lou J., McEver R.P. and Zhu C., 2005, "Force history dependence of receptor-ligand dissociation," Biophys. J., 88:1458-1466. Full Text in PDF

2004 Publications

40. Sarangapani K.K., Yago T., Klopocki A.G., Lawrence M.B., Fieger C.B. Rosen S.D. McEver R.P. and Zhu C., 2004, "Low force decelerates L-selectin dissociation from P-selectin glycoprotein ligand-1 and endoglycan," J. Biol. Chem., 279:2291-2298. Full Text in PDF

39. Evans E., Leung A., Heinrich V.,and Zhu C., 2004, "Mechanical switching and coupling between two dissociation pathways in a P-selectin adhesion bond" Proc. Natl. Acad. Sci. USA., 101:11281-11286. Full Text in PDF

38. Yago T., Wu J. H., Wey C. D., Klopocki1 A. G., Zhu C. and McEver R. P. 2004, "Catch bonds govern adhesion through L-selectin at threshold shear," J. Cell Biol., 166:913-923. Full Text in PDF

37. Huang J., Chen J., Chesla S. E., Yago. T., Mehta P., McEver R. P., Zhu C. and Long M. 2004, "Quantifying the effects of molecular orientation and length on two-dimensional receptor-ligand binding kinetics", J. Biol. Chem., 279:44915-44923. Full Text in PDF

36. Marcus, W. D., McEver R. P., Zhu C. and Long M. 2004, "Forces required to initiate membrane tether extrusion from cell surface depend on cell type but not on the surface molecule," Mechanics & Chemistry of Biosystems, 1:245-252. Full Text in PDF

2003 Publications

35. Marshall B.T., Long M., Piper J.W., Yago T., McEver R.P. and Zhu C., 2003, "Direct observation of catch bonds involving cell-adhesion molecules," Nature, 423:190-193. Full Text in PDF

http://gtresearchnews.gatech.edu/newsrelease/catchbond.htm

http://gtresearchnews.gatech.edu/reshor/rh-ss03/rlinkSS03.html#rlink2

2002 Publications

34. Li, P., Nagarajan, N., Zhu C. and Selvaraj, P., 2002, "Recombinant CD16A-Ig forms a homodimer and cross-blocks the ligand binding functions of neutrophil and monocyte Fc receptors," Mol. Immunol., 38:527-538. Full Text in PDF

33. Zhu C., Long M., Chesla SE., Bongrand P., 2002, "Measuring Receptor/Ligand Interaction at the Single-Bond Level: Experimental and Interpretative Issues," Ann. Biomed. Eng. 30:305-314. Full Text in PDF

32. Yago T., Leppanen A., Qiu Hy., Marcus W.D., Nollert M.U., Zhu C., Cummings R.D., McEver R.P., 2002, "Distinct molecular and cellular contributions to stabilizing selectin-mediated rolling under flow," J. Cell Biol. 158: 787–799. Full Text in PDF

2001 Publications

31. Dustin ML, Bromley SK , Davis MM and Zhu C, 2001, "Identification of self through two-dimensional chemistry and synapses," Annu. Rev. Cell Dev. Biol. 17:133-157. Full Text in PDF

30. Ramachandran V, Yago T, Epperson TK, Kobzdej MMA, Nollert MU, Cummings RD, Zhu C and McEver RP, 2001 "Dimerization of a selectin and its ligand stabilizes cell rolling and enhances tether strength in shear flow," Proc. Natl. Acad. Sci, USA. 98:10380–10385. Full Text in PDF

29. Pierres A, Benoliel A-M, Zhu C and Bongrand P, 2001, "Diffusion of microspheres in shear flow near a wall: use to measure binding rates between attached molecules," Biophys. J. 81:25-42. Full Text in PDF

28. Williams TE, Nagarajan S, Selvaraj P and Zhu C, 2001, "Quantifying the impact of membrane microtopology on effective two-dimensional affinity," J. Biol. Chem. 276:13283-13288. Full Text in PDF Supplement data

27. Long M, Zhao H, Huang K, Zhu C, 2001, "Kinetic Measurements of Cell Surface E-Selectin/Carbohydrate Ligand Interactions," Ann. Biomed. Eng. 29:935-946. Full Text in PDF Web Movie

2000 Publications

26. Zhao H., Zhu C., Li X.F., Dong X., Zhuang F., Wang X., and Stoltz J.-F., 2000, " Tetramethylpyrazine inhibits PHA-induced upregulation of ICAM-1/LFA-1 mdiated leukocyte adhesion," Clin. Hemorheol. Microcirc. 23: 145-151. Full Text in PDF

25. Zhu C and Williams TE, 2000, "Modeling concurrent binding of multiple molecular species in cell adhesion," Biophys. J. 79:1850-1857. Full Text in PDF

24. Williams TE, Selvaraj P and Zhu C, 2000, "Concurrent binding to multiple ligands: Kinetic rates of CD16b for member-bound IgG1 and IgG2," Biophys. J. 79:1858-1866. Full Text in PDF

23. Williams TE, Nagarajan S, Selvaraj P and Zhu C, 2000, "Concurrent and independent binding of Fcg receptors IIa and IIIb to surface-bound IgG," Biophys. J. 79:1867-1875. Full Text in PDF

22. Zhu C, Bao G and Wang N, 2000, "Cell mechanics: Mechanical responses, cell adhesion, and molecular deformation," Annu. Rev. Biomed. 2:189-226 Full Text in PDF

21. Xie WG, Peng HR, Zalkow LH, Li Y-H, Zhu C, Powis G and Kunkel M, 2000, "3 beta-hydroxy-6-aza-cholestane and related analogues as phosphatidylinositol specific phospholipase C (PI-PLC) inhibitors with antitumor activity," Bioorg. Med. Chem., 8:699-706. Full Text in PDF

20. Chesla SE, Li P, Nagarajan S, Selvaraj P and Zhu C, 2000, "The membrane anchor influences ligand binding 2D kinetics rates and 3D affinity of FcgRIII (CD16)," J. Biol. Chem. 275:10235-10246. Full Text in PDF

19. Nagarajan S, Venkiteswaran K, Anderson M, Sayed U, Zhu C and Selvaraj S, 2000, "Cell-specific, activation-dependent regulation of neutrophil CD32A ligand-binding function," Blood. 95:1069-1077. Full Text in PDF

18. Zhu C, 2000, "The kinetics and mechanics of cell adhesion," J. Biomech. 33:23-33. Full Text in PDF

1999 Publications

17. Li Y-H and Zhu C, 1999, "A modified Boyden chamber assay for tumor cell transendothelial immigration in vitro," Clin. Exp. Metastasis. 17:423-429. Full Text in PDF

16. Ramachandran V, Nollert MU, Qiu H, Liu W, Cummings RD, Zhu C and McEver RP, 1999 "Tyrosine replacement in P-selectin glycoprotein ligand-1 affects distinct kinetic and mechanical properties of bonds with P- and L-selectin," Proc. Natl. Acad. Sci, USA. 96:13771-13776. Full Text in PDF

15. Li P, Selvaraj P and Zhu C, 1999, "Analysis of competition binding between soluble and membrane-bound ligands for cell surface receptors," Biophys. J. 77:3394-3406. Full Text in PDF

14. Long M, Goldsmith HL, Tees DFJ and Zhu C, 1999, "Probabilistic modeling of shear-induced formation and breakage of doublets cross-linked by receptor-ligand bonds," Biophys. J. 76: 1112-1128. Full Text in PDF

1998 Publications

13. Chesla SE, Selvaraj P and Zhu C, 1998, "Measuring two-dimensional receptor-ligand binding kinetics by micropipette," Biophys. J. 75: 1553-1572. Full Text in PDF

12. Piper JW, Swerlick RA and Zhu C, 1998, "Determining force dependence of two-dimensional receptor-ligand binding affinity by centrifugation," Biophys. J. 74: 492-513. Full Text in PDF

Publications Before 1998

11. Nagarajan S, Chesla SE, Cobern L, Paul Andersoni, Zhu C and Selvaraj P, 1995, “Ligand Binding and Phagocytosis by CD16 (Fc g Receptor III) Isoforms”, J. Biol. Chem. 270: 25762–25770. Full Text in PDF

10. Yang J., XU Y.L., Zhu C, Hagan M.K., Lawley T., and Offermann M.K. 1994, “Regulation of Adhesion Molecule Expression in Kaposi’s Sarcoma Cells." J. Immunology. 152:361-373, Full Text in PDF

9. Sung, K.-L.P., Frojmovic, M.M., O'Toole, T.E., Zhu, C., Ginsberg, M.H. and Chien, S., "Determination of adhesion force between single cell pairs generated by activated GPIIb-IIIa receptors," Blood, vol. 81, pp. 419-423, January 1992. Full Text in PDF

8. Zhu, C., "A thermodynamic and biomechanical theory of cell adhesions. Part I: General formulism," J. Theor. Biol., vol. 150, pp. 27-50, May 1991 Full Text in PDF

7. Zhu, C., "Discontinuous dependency of plate strain energy on boundary contour," J. Eng. Mech., vol. 116, no. 12, pp. 2779-2783, December 1990

6. Skalak, R., Dong, C. and Zhu, C., "Passive deformations and active motions of leukocytes," J. Biomech. Eng. , vol. 112, no. 3, pp. 295-302, August 1990

5. Skalak, R. and Zhu, C., "Rheological aspects of red blood cell aggregation," Biorheol., vol. 27, no. 3 & 4, pp. 309-325, July 1990

4. Skalak, R., Zhu, C. and Dong, C., "Active motions of leukocytes," Studia Biophysica, vol. 134, no. 1 & 2, pp. 173-178, August, 1989

3. Zhu, C. and DiMaggio, F. L., "Contribution of Gaussian curvature to strain energy of plates," J. Eng. Mech., vol.115, no. 7, pp. 1434-1140, July 1989

2. Zhu, C., Skalak, R. and Schmid-Schönbein, G.W., "One-dimensional steady continuum model of retraction of pseudopod in leukocytes," J. Biomech. Eng. , vol. 111, no. 1, pp. 69-77, February 1989.

1. Zhu, C. and Skalak, R., "A continuum model of protrusion of pseudopod in leukocytes," Biophys. J., vol. 54, pp. 1115-1137, December 1988,

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