Wallace H. Coulter Department of Biomedical Engineering
 
Laboratory for Biomaterials and Molecular Imaging

Publications

  1. Lee S, Yang SC, Kao CY, Pierce RH, Murthy N. "Solid polymeric microparticles enhance the delivery of siRNA in vivo". Nucleic Acid Research (In Press 2009).
  2. Fiore VF, Lofton MC, Roser-Page S, Yang SC, Roman J, Murthy N, Barker TH. "Polyketal microparticles for therapeutic delivery to the lung". Biomaterials (In Press 2009).
  3. Seshadri G, Sy J, Dikhalov S, Murthy N, Davis M. "Delivery of SOD with polyketal particles protects rats from myocardial ischemia-reperfusion injury". Biomaterials (In Press 2009).
  4. Heffernan M, Murthy N. "Disulfide-crosslinked polyion micelles for delivery of protein therapeutics". Annals of Biomedical Engineering (2009), 37(10), 1993-2002.
  5. Lin P, Myers L, Ray L, Song S, Nasr T, Berardinelli A, Kundu K, Murthy N, Hansen J, Neish A. "Lactobacillus rhamnosus blocks inflammatory signaling in vivo via reactive oxygen species generation". Free Radical Biology & Medicine (2009), 47(8), 1205-1211.
  6. Dasari M, Lee D, Erigala V, Murthy N. "Chemiluminescent PEG-PCL micelles for imaging hydrogen peroxide". Journal of Biomedical Materials Research, Part A (2009), 89A(3), 561-566.
  7. Heffernan MJ, Kasturi SP, Yang S, Pulendran B, Murthy N. "The stimulation of CD8+ T cells by dendritic cells pulsed with polyketal microparticles containing ion-paired protein antigen and poly(inosinic acid)-poly(cytidylic acid)". Biomaterials (2009), 30 (5) 910-918.
  8. Kundu K, Knight S, Willett N, Lee S, Taylor W, Murthy N. "Hydrocyanines: A new class of fluorescent sensors that can image reactive oxygen species in cell culture, tissue and in vivo". Angewandte Chemie International (2009), 48 (2), 299-303.
  9. Sy J, Iyer G, Yang S, Brown M, Oh T, Dikalov S, Murthy N, Davis ME. "Sustained release of a p38-inhibitor from non-inflammatory microspheres inhibits cardiac dysfunction". Nature Materials. (2008), 7 (11), 863-868.
  10. Lee D, Erigala VR, Dasari M, Yu J, Dickson RM, Murthy N. "Detection of hydrogen peroxide with chemiluminescent micelles". International Journal of Nanomedicine (2008), 3 (4) 471-476.
  11. Gongora MC, Lob HE, Landmesser U, Guzik T, Martin WD, Ozumi K, Wall SM, Wilson DS, Murthy N, Gravanis M, Fukai T, Harrison DG. "Loss of extracellular SOD leads to acute lung damage in the presence of ambient oxygen-A potential mechanism underlying Adult Distress Respiratory Syndrome". American Journal of Pathology. (2008) 173 (4) 915-926.
  12. Cao W, Manicassamy S, Tang H, Kasturi S, Pirani A, Murthy N, Pulendran B. "Toll-like receptor mediated type I interferon induction in plasmacytoid dendritic cells requires the rapamycin-sensitive PI3K-mTOR-p70S6K pathway". Nature Immunology. (2008), 9 (10), 1157-1164.
  13. Yang SC, Bhide M, Crispe IN, Pierce RH, Murthy N. "Polyketal Copolymers: A new acid-sensitive delivery vehicle for treating acute inflammatory diseases". Bioconjugate Chemistry. (2008), 19 (6), 1164-1169.
  14. Sullivan S, Murthy N, Prausnitz M. "Minimally invasive protein delivery with rapidly dissolving polymer microneedles". Advanced Materials. (2008), 20(5), 933-938.
  15. Chung IM, Enemchukwu NO, Khaja SD, Murthy N, Mantalaris A, Garcia AJ. "Bioadhesive hydrogel microenvironments to modulate epithelial morphogenesis". Biomaterials. (2008), 29(17), 2637-2645.
  16. Lee D, Khaja S, Velasquez CJ, Dasari M, Sun C, Petros J, Taylor W, Murthy N. "In vivo imaging of hydrogen peroxide with chemiluminescent nanoparticles". Nature Materials. (2007), 6(10), 765-769.
  17. Lee S, Murthy N. "Targeted delivery of catalase and superoxide dismutase to macrophages using folate". Biochemical and Biophysical Research Communications. (2007), 360(1), 275-279.
  18. Khaja S, Lee S, and Murthy, N. "Acid degradable protein delivery vehicles based on metathesis chemistry". Biomacromolecules. (2007) 8(5), 1391-1395.
  19. Lee S, Yang SC, Heffernan MJ, Taylor WR, and Murthy N. "Polyketal microparticles: a new delivery vehicle for superoxide dismutase". Bioconjugate Chemistry. (2007), 18(1), 4-7.
  20. Talsma S, Babensee J, Murthy N, Wiliams R. "Development and in vitro validation of a targeted delivery vehicle for DNA vaccines". Journal of Controlled Release. (2006), 112(2), 271-279.
  21. Hao J, Kwissa M, Pulendran B, Murthy N. "Peptide crosslinked micelles: A new strategy for the design and synthesis of peptide vaccines". International Journal of Nanomedicine. (2006), (1), 97-103.
  22. Heffernan M, Murthy N. "Polyketal nanoparticles: A new pH sensitive biodegradable drug delivery vehicle". Bioconjugate Chemistry. (2005), 16(6), 1340-1342.

From postdoctoral and graduate work

  1. Standley SM, Kwon YJ, Murthy N, Kunisawa J, Shastri N, Guillaudeu SJ, Lau L, Fréchet JMJ.  "Acid-degradable particles for protein-based vaccines: Enhanced survival rate for tumor-challenged mice using ovalbumin model". Bioconjugate Chemistry. (2004), 15(6), 1281-1288.
  2. Goh SL, Murthy N, Xu M, Frechet JMJ. "Cross-linked microparticles as carriers for the delivery of plasmid DNA for vaccine development". Bioconjugate Chemistry. (2004), 15(3), 467-474.
  3. Bulmus V, Woodward M, Lianne L, Murthy N, Stayton P, Hoffman A. "A new pH-responsive and glutathione-reactive, endosomal membrane-disruptive polymeric carrier for intracellular delivery of biomolecular drugs". Journal of Controlled Release. (2003), 93(2), 105-120.
  4. Murthy N, Xu M, Schuck S, Kunisawa J, Shastri N, Fréchet JMJ. "A new delivery vehicle for protein based vaccines: Acid degradable protein loaded microgels". Proceedings of the National Academy of Sciences (2003), 100(9), 4995-5000.
  5. Murthy N, Campbell J, Fausto N, Hoffman AS, Stayton PS.  "Bioinspired pH-responsive polymers for the intracellular delivery of biomolecular drugs". Bioconjugate Chemistry. (2003), 14(2), 412-419.
  6. Murthy N, Campbell J, Fausto N, Hoffman A, Stayton S. "pH responsive polymeric carriers that target uptake and enhance the intracellular delivery of oligonucleotides". Journal of Controlled Release. (2003), 89(3), 365-374.
  7. Murthy N, Thng Y, Schuck S, Xu M, Fréchet JMJ. "A novel strategy for encapsulation and release of proteins: hydrogels and microgels with acid-labile acetal crosslinkers". Journal of the American Chemical Society. (2002), 124(42), 12398-12399.
  8. Kyriakides TR, Cheung C, Murthy N, Bornstein P, Stayton PS, Hoffman AS. "pH-sensitive polymers that enhance intracellular drug delivery in vivo".  Journal of Controlled Release. (2002), 78(1-3), 295-303.
  9. Hoffman AS, Stayton PS, Press O, Murthy N, Lackey AC, Cheung C, Black F, Campbell J, Fausto N, Kyriakides TR, Bornstein P.  "Design of smart polymers that can direct intracellular drug delivery". Polymers for Advanced Technologies. (2002), 13(10-12), 992-999.
  10. Cheung C, Murthy N, Stayton P, Hoffman A. "A pH-sensitive polymer that enhances cationic lipid-mediated gene transfer". Bioconjugate Chemistry. (2001), 12(6), 906-91.
  11. Hoffman AS, Stayton PS, Press O, Murthy N, Lackey C, Cheung C, Black F, Campbell J, Fausto N, Kyriakides TR, Bornstein P. "Bio-inspired polymers that control intracellular drug delivery".  Biotechnology and Bioprocess Engineering. (2001), 6(4), 205-212.
  12. Murthy N, Chang I, Stayton P, Hoffman A. "pH-sensitive hemolysis by random copolymers of alkyl acrylates and acrylic acid". Macromolecular Symposia. (2001), 172(1) (Polymers in Medicine), 49-55.
  13. Mourad PD, Murthy N, Porter T, Poliachik SL, Crum L, Hoffman AS, Stayton PS. "Focused ultrasound and poly(2-ethylacrylic acid) act synergistically to disrupt lipid bilayers in vitro". Macromolecules. (2001), 34(8), 2400-2401.
  14. Stayton PS, Hoffman AS, Murthy N, Lackey C, Cheung C, Tan P, Klumb LA, Chilkoti A, Wilbur FS, Press OW. "Molecular engineering of proteins and polymers for targeting and intracellular delivery of therapeutics". Journal of Controlled Release. (2000), 65(1-2), 203-220.
  15. Murthy N, Robichaud J, Tirrell DA, Stayton PS, Hoffman AS. "The design and synthesis of polymers for eukaryotic membrane disruption".  Journal of Controlled Release. (1999), 61(1-2), 137-143.
  16. Lackey C, Murthy N, Press OW, Tirrell DA, Hoffman AS, Stayton PS. "Hemolytic activity of pH-responsive polymer-streptavidin bioconjugates". Bioconjugate Chemistry. (1999), 10(3), 401-405.
  17. Murthy N, Subramanian U, Anant S, Subramanian KN.  "The replication inhibition activity of the WT1 tumor suppressor protein resides in its N-terminal 298 amino acid region, and does not require specific binding of the protein to the replication origin sequence". International Journal of Oncology. (1998), 13(6), 1275-1280.