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The McDevitt ESCT Laboratory at Georgia Tech

Engineering Principles Applied to Stem Cell Biology to Advance Regenerative Medicine and Cell Diagnostic Technologies

The McDevitt laboratory is focused on the engineering of innovative technologies to translate the regenerative potential of stem cells into effective cellular and molecular therapies for the treatment of degenerative diseases and traumatic injuries.  By developing controlled systems approaches to engineer
the microenvironment of
stem cells, we aspire to improve the efficiency and yield of directed stem cell differentiation strategies. 
We also seek to develop
novel regenerative molecular therapies based on the morphogens produced by stem cells.  Efficient scalable bioprocesses will require the development of enabling tools and technologies to facilitate the production of stem cell technologies. The combination of directed stem cell differentiation and derivation of stem cell biotherapeutics will yield fresh insights into stem cell biology and facilitate new regenerative therapies.


ESCT Lab Research Themes

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Engineering the Stem Cell Microenvironment
Spatiotemporal control of biochemical and mechanical cues in the extracellular stem cell microenvironment can be used to direct cell phenotype. (more)

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Stem Cell Bioprocessing
Engineering controlled systems for the scalable efficient production of stem cells requires the development of novel enabling tools and technologies. (more)


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Regenerative Stem Cell Molecular Therapies
Morphogenic factors produced by stem cells can induce endogenous repair of injured and diseased tissues, independent of cell differentiation. (more)

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Stem Cell Biology & Related Projects
The ever-expanding landscape of stem cell biology continues to create new avenues of research and collaborative opportunities to pursue. (more)