Biography

Dr. Davis holds positions as an Assistant Professor in both Cardiology and Biomedical Engineering at the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University.  He received his Ph.D. in Molecular and Systems Pharmacology at Emory University in 2003 working on molecular regulation of eNOS expression by shear stress.  From 2003-2006, he completed his postdoctoral fellowship at Brigham and Women’s Hospital working on cardiac tissue engineering with collaborators at the Massachusetts Institute of Technology.  He moved back to Emory in 2006 to join the faculty in Division of Cardiology and Biomedical Engineering Department.

Honors and Awards

2000 NIH Departmental Training Grant Recipient
2002 Achievement Rewards for College Scientists (ARCS) Award
2005 Keystone Symposium Scholarship Award

Patents

2005 US Patent Application 20060088510; Lee RT and Davis ME "Targeted delivery of biological factors using self-assembling peptide nanofibers."

Publications

Davis ME, Hsieh PCH, Takahashi T, Song Q, Kamm RD, Zhang S Grodzinksy AJ and Lee RT.  Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction.  Proc Natl Acad Sci U S A. 2006 May 23;103(21):8155-60.

Hsieh PCH, Davis ME and Lee RT.  Controlled delivery of PDGF-BB, and endothelial-derived cardiomyocyte survival factor, for myocardial protection using injectable self-assembling peptide nanofibers.  J Clin Invest, 2006 Jan;116(1):237-48.

Davis ME, Motion JPM, Narmoneva D, Takahashi T, Kamm RD, Zhang S and Lee RT.  Injectable self-assembling peptide nanofibers create intramyocardial microenvironments for endothelial cells.  Circulation. 2005 Feb 1;111(4):442-50.

Narmoneva D, Vukmirovic R, Davis ME, Kamm RD and Lee RT.  Endothelial cells promote cardiac myocyte survival and spatial reorganization: implications for cardiac regeneration. Circulation. 2004 Aug 24;110(8):962-8.

Searles CD, Ide L, Davis ME, Cai H and Weber M.  Actin cytoskeleton organization and posttranscriptional regulation of endothelial nitric oxide synthase during cell growth.  Circ Res. 2004 Sep 3;95(5):488-95.

McNally JS, Davis ME, Giddens DP, Saha A, Hwang J, Dikalov S, Jo H and Harrison DG.  Role of Xanthine Oxidoreductase and the NAD(P)H oxidase in Endothelial Superoxide Production in Response to Oscillatory Shear Stress.  Am J Physiol Heart Circ Physiol. 2003 Dec;285(6):H2290-7.

Davis ME, Grumbach IM, Fukai T, Cutchins A and Harrison DG.  NFkB regulates induction of endothelial nitric oxide synthase promoter activation in response to unidirectional shear stress. J Biol Chem. 2004 Jan 2;279(1):163-8.

Davis ME, Cai H, McCann L, Fukai T and Harrison DG.  Role of c-Src in regulation of endothelial nitric oxide synthase expression during exercise training.  Am J Physiol Heart Circ Physiol 2003 Apr;284(4):H1449-53.

Cai H, Li Z, Davis ME, Kanner W, Harrison DG, Dudley SC.  Akt-dependent phosphorylation of serine 1179 and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase 1/2 cooperatively mediate activation of the endothelial nitric-oxide synthase by hydrogen peroxide. Mol Pharmacol. 2003 Feb;63(2):325-331.

Davis ME, Drummond GR, Cai H, and Harrison DG.  Shear stress regulates endothelial nitric oxide synthase expression through c-Src by divergent signaling pathways.  Circ Res. 2001 Nov 23;89(12):1073-108.

Cai H, Davis ME, Drummond GR and Harrison DG.  Induction of endothelial NO synthase by hydrogen peroxide via a Ca(2+)/calmodulin-dependent protein kinase II/janus kinase 2-dependent pathway.  Arterioscler Thromb Vasc Biol. 2001 Oct;21(10):1571-6.

Drummond GR, Cai H, Davis ME, Ramasamy S, and Harrison DG.  Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide.  Circ Res. 2000 Feb 18;86(3):347-54.