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research Cell Adhesion and Inflammation in Sickle Cell Disease Sickle Cell Disease (SCD) is characterized by abnormal cell adhesion behavior between leukocytes, red blood cells (RBCs), and the endothelium. Patients with SCD exhibit elevated markers of vascular inflammation in serum (leukocytes counts, inflammatory cytokines, soluble adhesion molecules). Research Goal: To investigate the involvement of adherent leukocytes in sickle vascular occlusion and assist in the development of anti-inflammatory compounds for therapeutic intervention against pathological cell adhesion and inflammation
Quantifying
Cell Adhesion Behavior Under Flow and A parallel plate flow chamber and video microscopy are used to observe blood cell interactions under physiologically relevant low shear conditions.
Cartilage Tissue Engineering Research Goal: To increase understanding of the role of hydrodynamic environment plays on the cultivation of cartilage with clinically useful properties
Modeling the hydrodynamic
Environment in the Spinner Flask The magnitude and location of the fluid-induced shear stresses applied on the surface of tissue constructs is affected by their position in the wavy-walled bioreactor (WWB). |
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The Wallace H. Coulter Department of Biomedical Engineering |
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