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Thomas Barker Thomas Barker, Ph.D.
Associate Professor
Petit Faculty Fellow

Wallace H. Coulter Dept. of Biomedical Engineering
Georgia Institute of Technology
Atlanta, GA 30332-0535

Phone: 404-385-5039
Fax: 404-894-4243
Location: GT: BME - 2108
E-Mail: thomas.barker@bme.gatech.edu
URL: http://barker.bme.gatech.edu

Google Scholar: CLICK HERE

Areas of Research

    Cell-Extracellular Matrix (ECM) interactions, ECM-directed cell differentiation in regeneration and pathogenesis, Cell and Molecular Mechanobiology, ECM-inspired Biomaterials for Regenerative Medicine applications.

Educational Background

  • UWEB Postdoctoral Fellow, University of Washington and The Hope Heart Institute, Seattle WA, 2003-2004
  • Ph.D., University of Alabama at Birmingham (UAB), 2003
  • M.S., University of Alabama at Birmingham (UAB), 2000
  • B.S., Oglethorpe University, 1995

Selected Awards

  • 2004, Ruth L. Kirchstein Postdoctoral Fellow, NIGMS
  • 2002, National NASA Space Fellow, Division of Physical and Biological Sciences, NASA HQ
  • 2001, Keystone Symposia (D3) Cell Adhesion and Migration Outstanding Research Award

Selected Research Publications

  • Schultz CR, Golembieski WA, Yunker CK, Thomas SL, Barker TH, Sage EH, Rempel SA. SPARC-induced Changes in Glioma Proliferation, Migration, Adhesion, and Cytoskeletal Structure on Fibronectin are Accompanied by ILK Interaction, Akt, ERK1/2, p38MAPK, and Hsp27 Upregulation and/or Phosphorylation Depending on the Growth Conditions. Glia 56(10): 1061-75, 2008.
  • Sullivan MM, Barker TH, Funk S, Lara S, Karchin A, Sanders J, Starcher B, Wight TN, Puolakkainen PA Sage EH. Matricellular Hevin Influences Dermal Architecture and Wound Closure in vivo and Inhibits Adhesion and Migration by Cultured Dermal Fibroblasts. J Biol Chem 281(37): 27621-27632, 2006.
  • Barker TH, Banyx G, Cardo-Vila M, Workman GA, Weaver M, Menon PM, Dedhar S, Rempel SA, Arap W, Pasqualini R, Vogel V, Sage EH. SPARC regulates extracellular matrix organization through its modulation of integrin-linked kinase activity, J Biol Chem 280(43): 36483-36493, 2005.
  • Hagood JS, Prabhakaran P, Kumbla P, Salazar L, MacEwen MW, Barker TH, Ortiz LA, Schoeb T, Siegal GP, Alexander CB, Pardo A, Selman M. Loss of Fibroblast Thy-1 Expression Correlates with Lung Fibrogenesis. Am J Pathol 167 (2): 365-79, 2005.
  • Barker TH, Framson P, Poulakkainen P, Reed M, Funk S, Sage EH. Matricellular Homologs in the Foreign Body Response: Hevin suppresses Inflammation, but Hevin and SPARC Together Diminish Angiogenesis, Am J Pathol 166(3):923-33 2005.
  • Barker TH, Pallero MA, MacEwen MW, Tilden SG, Woods A, Murphy-Ullrich JE, Hagood JS. Thrombospondin-1-induced focal adhesion disassembly in fibroblasts requires Thy-1 surface expression, lipid raft integrity, and src activation. J Biol Chem 279 (22): 23510-6, 2004.


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