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Areas of Research
- Spinal cord functional systems - pain, plasticity, injury and regeneration, motor
pattern generation, restless leg syndrome, autonomic controls, novel
interface devices.
- Techniques:
Electrophysiology - Whole-cell patch clamp, extracellular recordings, electroneurograms.
Receptor pharmacology - Serotonin, dopamine, nor-adrenaline, acetylcholine.
Immunoctyochemistry - Serotonin, dopamine, nor-adrenaline and acetylcholine receptors. Ca2+ binding proteins, neuropeptides.
- Molecular biology - Expression profiling (DNA microarrays) and LCM (laser capture microdissection), in situ hybridization, real-time PCR.
Educational Background
- PhD, University of Manitoba, Canada 1989
- Postdoc, University of Toronto, 1992
- Assistant Professor, University of Manitoba, 1994-1999
Selected Awards
- NIH (1 R01 NS40440-01). Properties of the mammalian spinal locomotor network.
- NIH (1 R01 NS40893-01). Serotonin and spinal reflex plasticity.
- NIH (1 R01 NS45248-01A1). Dopaminergic control of spinal cord and restless legs.
Restless Legs Syndrome Foundation. Spinal dopamine dysfunction and
>restless legs syndrome.
- GTEC. A paradigm shift in spinal cord bridge construction across a lesion: Miniaturization and multiplication.
Selected Research Publications
- Song, L., Nath, A., Moore, A., Geiger, J.D., and Hochman, S.
"HIV-1 Tat protein directly activates neuronal NMDA receptors at an
allosteric zinc-sensitive site."Journal of Neurovirology, 9:399-403 (2003).
- Macdonald, S.C., Fleetwood, I.G., Hochman, S., Brownstone, R., Dodd, J.G., Cheng, K.W., and Jordan, L.M.
"Functional motor neurons differentiating from mouse multipotent spinal cord
precursors in culture and after transplantation into transected sciatic
nerve."J. Neurosurgery, 98:1094-1103 (2003).
- Cowley, K.C., Cina, C, Schmidt, B.J., and Hochman, S."The isolated rat spinal cord as an in vitro model to study the pharmacological control of spinal myoclonic-like activity." Advances of Neurology, Fahn and Frucht Eds. Lippincott Williams & Wilkins. 89:275-87, 2002.
- Hochman S., Garraway, S.M.. Machacek, D.W. and Shay,
B.L., " 5-HT receptors and the neuromodulatory control of spinal cord function." In: Motor Neurobiology of the Spinal Cord. CRC Press, Boca Raton T.C.Cope. (ed). p47-87, 2001.
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