|
Areas of Research
- Mechanisms of cell-cell adhesion.
- Cadherin endocytosis and membrane trafficking.
- Cytoskeletal interactions with the plasma membrane.
- Disruption of adhesion in the skin disease Pemphigus.
Educational Background
- Ph.D. Physiology and Cell Biology, Albany Medical College, 1992
Selected Awards
- 2003 - 2005, Peggy McCreedy Schwall Grant in Aid - American Heart Association
- 2000, Diana Ashby Memorial Research Award - Melanoma Research Foundation
Selected Research Publications
- Calkins, C.C., Setzer, S.V., Jennings, JM., Summers, S., Tsunoda, K., Amagai, M., and Kowalczyk, A.P. 2006. Desmoglein endocytosis and desmosome disassembly are coordinated responses to Pemphigus autoantibodies. J. Biol. Chem. Vol. 281: 7623-7634.
- Xiao K, Garner J, Buckley KM, Vincent PA, Chiasson CM, Dejana E, Faundez V, Kowalczyk AP. 2005. p120-catenin regulates clathrin-dependent endocytosis of VE-cadherin. Mol. Biol. Cell. Vol. 16:5141-5151.
- Xiao, K., Allison, D.F., Buckley, K.M., Kottke, M., Vincent, P.A., Faundez, V. and Kowalczyk, A.P. 2003. Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells. J. Cell Biol. 163(3):535-45.
- Calkins, C.C., Law,C.M., Hoepner,B., Novak,M.R., Hatzfeld,M. and Kowalczyk,A.P. 2003. " The Armadillo family protein p0071 is a VE-cadherin and desmoplakin-binding Protein." J. Biol. Chem. Vol 278(3):1774-83
- Xiao K, Allison DF, Kottke MD, Summers S, Sorescu GP, Faundez V, Kowalczyk AP. 2003. " Mechanisms of VE-cadherin processing and degradation in microvascular endothelial cells." J.Biol Chem. 278(21):19199-19208.
|
