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Areas of Research
New Materials for the Delivery of Biotherapeutics.
Educational Background
- Postdoctoral Fellow, University of California at Berkeley, Department of Chemistry, 2001-2003
- Ph.D. University of Washington, 2001
- M.S. University of Illinois, 1996
- B.S. University of Redlands, 1992
Selected Awards
- 2008, Indus Global Innovators Award
- 2006, NSF CAREER AWARD
- 2003, Petit Fellowship, Georgia Institute of Technology
- 1998, Cygnus Outstanding graduate student award, Controlled Release Society
Selected Research Publications
- Cao W, Manicassamy S, Tang H, Kasturi S, Pirani A, Murthy N, Pulendran
B. Toll-like receptor mediated type I interferon induction in
plasmacytoid dendritic cells requires the rapamycin-sensitive
PI3K-mTOR-p70S6K pathway. Nature Immunology (In Press, Published
Online August 4th 2008).
- Sullivan S, Murthy N, Prausnitz M. Minimally invasive protein delivery with rapidly dissolving polymer microneedles. Advanced Materials 20 (5) 933-938, 2008.
- Lee D, Khaja S, Velasquez CJ, Dasari M, Sun C, Petros J, Taylor W, Murthy N. In vivo imaging of hydrogen peroxide with chemiluminescent nanoparticles. Nature Materials 6(10), 765-769, 2007.
- Lee S, Murthy N. Targeted delivery of catalase and superoxide dismutase to macrophages using folate. Biochemical and Biophysical Research Communications 360(1), 275-279, 2007.
- Khaja S, Lee S, and Murthy N. Acid degradable protein delivery vehicles based on metathesis chemistry. Biomacromolecules 8(5), 1391-1395, 2007.
- Lee S, Yang SC, Heffernan MJ, Taylor WR, Murthy N. Polyketal microparticles: a new delivery vehicle for superoxide dismutase. Bioconj. Chem. 18(1) 4-7, 2007.
- Talsma S, Babensee J, Murthy N, Wiliams R. Development and in vitro validation of a targeted delivery vehicle for DNA vaccines. J Control Release 112(2): 271-9, 2006.
- Hao J, Kwissa M, Pulendran B, Murthy N. Peptide crosslinked micelles: A new strategy for the design and synthesis of peptide vaccines. International Journal of Nanomedicine 1, 97-103, 2006.
- Heffernan M; Murthy N. Polyketal nanoparticles: A new pH sensitive biodegradable drug delivery vehicle. Bioconj. Chem. 16(6): 1340-1342, 2005.
- Murthy N, Xu M, Schuck S, Kunisawa J, Shastri N, Frechet J. A new delivery vehicle for protein based vaccines: Acid degradable protein loaded microgels. Proc. Natl. Acad. Sci. 100, 4995-5000, 2003.
- Murthy N, Campbell J, Fausto N, Hoffman AS, Stayton PS. Bioinspired pH-Responsive Polymers for the Intracellular Delivery of Biomolecular Drugs. Bioconjugate Chemistry 14(2), 412-419, 2003.
- Murthy N, Campbell J, Fausto N, Hoffman A, Stayton S. pH Responsive Polymeric Carriers That Target Uptake and Enhance The Intracellular Delivery of Oligonucleotides. Journal of Controlled Release 89, 365-374, 2003.
- Murthy N, Thng YX, Schuck S, Xu MC, Frechet JM. A novel strategy for encapsulation and release of proteins: hydrogels and microgels with acid-labile acetal crosslinkers. J. Am. Chem. Soc. 124, 12398-12399, 2002.
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