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Areas of Research
Our research is in the areas of biomolecular engineering and nanotechnology, with a focus on bioconjugated nanoparticles for cancer molecular imaging, molecular profiling, pharmacogenomics, and targeted therapy. Specific topics include the following:
1. Bioconjugated Nanoparticle Probes for Molecular and Cellular Imaging
2. Molecular Profiling for Personalized and Predictive Oncology
3. Drug Delivery and Targeting for Individualized Therapy
4. New Technology for Ultrasensitive Cancer Detection/Screening
5. Single-Molecule Imaging of Intracellular Transport and Signaling
6. Cell-Based Therapy and Regenerative Medicine
Educational Background
- Postdoctoral Fellow, Stanford University, 1992-1994
- Postdoctoral Fellow, Georgia Institute of Technology, 1990-92
- Ph.D., Northwestern University, 1989
- M.S., Northwestern University, 1985
- B.S., Nankai University, College of Chemistry and Chemical Engineering, 1983
Selected Awards
- 2007, Georgia Cancer Coalition (GCC) Special Achievement Award
- 2007, HEINRICH-EMANUEL-MERCK AWARD FOR ANALYTICAL CHEMISTRY, Merck KGaA, Darmstadt, Germany
- 2007, Elected Fellow, American Institute of Medical and Biological Engineering (AIMBE), Washington DC.
- 2006, Cheung Kong Distinguished Professorship, The Chinese Ministry of Education.
- 2005, Rank Prize (The Rank Prize Funds, London, UK), for the Realization of Quantum Dot Nanocrystals as Biological Labels.
Selected Research Publications
- X. M. Qian, X.H. Peng, D. O. Ansari, Q. Yin-Goen, G. Z. Chen, D. M. Shin, L. Yang, A. N. Young, M. D. Wang, and S. M. Nie, “In-vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags,” Nature Biotechnology 2008, 26, 83-90.
- A. Agrawal, R. Deo, G. D. Wang, M. D. Wang, and S. M. Nie, “Nanometer-scale mapping and single molecule detection with color-coded nanoparticle probes,”” Proc. Natl. Acad. Sci. USA, 2008, 105, 3298-3303.
- K. Cho, X. Wang, S. M. Nie, Z. Chen, and D. M. Shin, “Therapeutic nanoparticles for drug delivery in cancer,” Clin. Cancer Res. 2008, 14, 1310-1316.
- G. Ruan, A. Agrawal, A. I. Marcus, and S. M. Nie, “Imaging and Tracking Tat-Peptide Conjugated Quantum Dots in Living Cells: New Insights into Nanoparticle Uptake, Intracellular Transport, and Vesicle Shedding,” J. Am. Chem. Soc, 2007, 129, 14759-14766.
- Y. Xing, G. Kim, and S. M. Nie, “Nanotechnology Applications in Cancer,” Annu. Rev. Biomed. Eng. 2007, 9, 257–288.
- Y. Xing, M. D. Wang, and S. M. Nie, “Bioconjugated Quantum Dots for Multiplexed and Quantitative Immunohistochemistry,” Nature Protocols 2007, 2, 1152-1165.
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