Areas of Research
Cellular Mechanics, BioMEMs/microfabrication/microfluidics, hematology (platelet and leukocyte biology, sickle cell disease, thrombosis), Endothelial cell biology, Cancer, Pediatric Medical Devices and Diagnostics
- Postdoctoral Fellow, UC Berkeley, 2008-2010
- Ph.D., UCSF/UC Berkeley Joint Graduate Group in Bioengineering, 2008
- Fellowship in Pediatric Hematology/Oncology, UCSF, 2002-2008
- Residency in Pediatrics, UCSF, 1999-2002
- M.D., Baylor College of Medicine, 1999
- B.A., Rice University, 1995
- 2012, NSF CAREER Award
- 2009-present, Mentored Clinical Scientist Research Career Development Award, NIH (NHLBI)
- 2009, Vodafone Americans Foundation Wireless Innovation Project - CellScope: Mobile Microscopy for Disease Diagnosis, 1st prize
- 2008, Melvin M. Grumbach Award for Excellence in Research at UCSF
- 2004-2008, Ruth L. Kirschstein National Research Service Award, NIH (NHLBI)
- 2003, Outstanding Clinical Postdoctoral Fellow Teaching Award, UCSF
- 2002, Outstanding Resident Teaching Award, UCSF
- 2001, Outstanding Resident Teaching Award, UCSF
Selected Research Publications
- Tsai M, Kita A, Leach J, Rounsevell R, Huang JN, Moake J, Ware RE, Fletcher DA, Lam WA. "In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology" J Clin Invest. 2012 Jan 3;122(1):408-18
- Kita A, Sakurai Y, Myers DR, Rounsevell R, Huang JN, Seok TJ, Yu K, Wu MC, Fletcher DA, Lam WA. "Microenvironmental geometry guides platelet adhesion and spreading: a quantitative analysis at the single cell level" PLoS One. 011;6(10):e26437.
- Lam WA, Chaudhuri O, Kita A, Li T, Crow A, Webster K, Huang J, Fletcher DA. “Single platelet mechanics and dynamics of contraction” Nature Materials. 2011 Jan;10(1).
- Lam WA, Cao L, Umesh V, Keung A, Sen S, Kumar S. “Extracellular matrix rigidity modulates neuroblastoma cell differentiation and N-myc expression” Mol Cancer. 2010 Feb 10;9:35.
- Breslauer DN, Maamari RN, Switz NA, Lam WA, Fletcher DA. “Mobile phone based clinical microscopy for global health applications.” PLoS One. 2009 Jul 22;4(7):e6320.
- Chaudhuri O, Parekh SH, Lam WA, Fletcher DA. “Combined atomic force microscopy and side-view optical imaging for mechanical studies of cells” Nature Methods. 2009 May; 6(5):383-7.
- Hsiao SC, Crow AK, Lam WA, Bertozzi CR, Fletcher DA, Francis MB. “DNA-coated AFM Cantilevers for the Investigation of Cell Adhesion and Patterning of Live Cells” Angewandte Chemie. 2008, 47(44):8473-7.
- Lam WA, Rosenbluth MJ, Fletcher DA. “Increased leukemia cell stiffness is associated with symptoms of leukostasis in pediatric acute lymphoblastic leukemia” British Journal of Haematology. 2008 August, 142(3), 497-501.
- Rosenbluth MJ*, Lam WA*, Fletcher DA. “Analysis of Blood Cell Mechanics Using Microfluidic Biophysical Flow Cytometry.” Lab on a Chip. 2008, 8, 1062 - 1070.
*both authors contributed equally to this work