Areas of Research
- Cellular and tissue engineering for connective tissue applications
- Cell adhesion and extracellular matrices
- Substrate modulation of protein adsorption and cellular function
- Musculoskeletal biomaterials and biomechanics
- Applications of bioactive materials in hard and soft tissue reconstruction and drug delivery
- Momentum and mass transport phenomena associated with biomaterials
- Ph.D. Bioengineering, University of Pennsylvania, 1996
- M.S.E. Bioengineering, University of Pennsylvania, 1992
- B.S. Mechanical Engineering, Cornell University, 1991
- Ford Foundation Postdoctoral Fellowship, 1997-1998
- Solomon R. Pollack Award for excellence in Graduate Bioengineering Research, University of Pennsylvania, 1997
- National Institute of Arthritis and Musculoskeletal and Skin Disorders Minority Travel Award, 1997
Selected Research Publications
- Garcia, A.J., Huber, F., and Boettiger, D. Force required to break alpha5beta1 integrin-fibronectin bonds in intact adherent cells is sensitive to integrin activation state.
Journal of Biological Chemistry 273: 10988-10993 (1998).
- Garcia, A.J., Vega, M.D., and Boettiger, D. Modulation of cell proliferation and differentiation through substrate-dependent changes in fibronectin conformation. Molecular
Biology of the Cell 10: 785-798 (1999).
- Garcia, A.J. and Boettiger, D. Integrin-fibronectin interactions at the cell-material interface: initial integrin binding and signaling. Biomaterials 20: 2427-2433 (1999).
Stephansson, S.N., Byers, B.A., and Garcia, A.J. Enhanced expression of the osteoblastic phenotype on substrates that modulate fibronectin conformation and integrin
receptor binding. Biomaterials (in press).