Areas of Research
Closed loop microstimulation for epilepsy. Developing novel multimicroelectrode recording/stimulation systems for treating focal epilepsy in the tetanus toxin rat model of epilepsy. [Rolston et al., Front. Neuroengineering, 2009;2:12]
Optogenetic control for epilepsy. Developing the use of gene-transfer of light-activated ion channels to control epileptic activity in our rat model of epilepsy.
Optimizing deep brain stimulation for epilepsy. Using multimicroelectrode arrays to study and optimize the effects of electrical stimulation of deep brain structures (e.g. subthalamic nucleus) on hippocampal epileptic activity.
Human microelectrode recording in epilepsy. Have been developing the use of multielectrode arrays to examine the nature of epileptic hippocampal tissue and other tissue in patients with epilepsy. This will be used in conjunction with electrical stimulation to examine the effects on neural activity of brain stimulation.
Cellular response of neural tissue to chronic brain stimulation. Examining effects of DBS on brain tissue response, including microglial reaction, using human postmortem material. [McConnell et al., J Neural Engineering 2009;6]
Development of novel gene therapy vectors to improve CNS regeneration. Designing and producing lentivirus and AAV vectors to interfere with intracellular signal transduction pathways mediating the effects of CNS axon growth inhibitors. [Mei et al., Cell Transplantation, 2007;16:245-262]. Also, collaborating with Dr. Ling Wei to examine the effects of these vectors on embryonic stem cells.
- M.D., PhD. (Molecular Pharmacology), Albert Einstein College of Medicine
- B.S., (Neural Science), Brown University
- NIH Medical Scientist Training Program Scholar (1982-1990)
- The Elsberg Award for Excellence in Resident Research, NY Soc for Neurosurg (1995)
- The Leo M. Davidoff Society Certificate of Distinction, Albert Einstein Coll Medicine (1996)
- Botterell Fellowship in Neurosurgery, Univ Toronto (1996-1998)
- Young Clinician Investigator Award, Amer Assn of Neurological Surgeons (1999-2000)
- Charles A. Elsberg Fellowship for Laboratory and Clinical Research for Neurological Surgery, NY Academy of Medicine (2000-2001)
Selected Research Publications
- Gross, R.E., Jones, E.J., Dostrovsky, J.O., Bergeron C., Lang, A.E., Lozano, A.M. Histological analysis of the location of effective thalamic stimulation for tremor. J Neurosurg 2004;100:547-552.
- Gross, R.E., Krack P, Rodriquez-Oroz, M., Rezai A. R., Benabid, A-L. Electrophysiological mapping for the implantation of deep brain stimulators for Parkinsonís disease and tremor. Mov Disord, 2006;Suppl 14:S259-83.
- Gross, R.E., Mei, Q., Gutekunst, C.-A., Torre, E. The pivotal role of RhoA GTPase in the molecular signaling of axon growth inhibition after CNS injury and targeted therapeutic strategies. Cell Transplantation, 2007;16:245-262.
- Gross RE, Rolston JD. The clinical utility of methods to determine spatial extent and volume of tissue activated by deep brain stimulation. Clin Neurophysiology 2008;119:1947-1950.
- Rolston JD, Gross RE, Potter SM. A low-cost multielectrode system for data acquisition enabling real-time closed-loop processing with rapid recovery from stimulation artifacts. Front Neuroeng. 2009;2:12.
- McConnell GC, Rees HD, Levey AI, Gutekunst C-A, Gross RE, Bellamkonda RV. Implanted neural electrodes cause chronic, local inflammation that is correlated with local neurodegeneration. J Neural Eng 2009;6