Genetic engineering, Protein engineering, Self-assembly, Smart Materials, Phase separation, Repetitive DNAs
My lab engineers self-assembling materials that are genetically-encoded and stimuli-responsive. Using these materials, together with genetic and protein engineering tools, we tackle exciting challenges in nanotechnology, biotechnology and medicine. As curious engineers, our work has led us to dissect the DNA and genomic parts that encode for such material systems and their emergent biophysical properties at the DNA/genome and protein levels. To learn new principles of self-assembly and stimuli-responsiveness, we take a bioinspired approach. We probe and manipulate self-assembly phenomena within cells and tissues. The resulting findings illuminate fundamental aspects of biology and serve as foundation to engineer advanced biomaterials.