Biomedical systems, metabolic pathways, biochemical systems theory, S-systems
It is our vision that one day mathematics and computation will be capable of reliably predicting, manipulating and optimizing biomedical systems for the advancement of medicine, drug development, biotechnology and productive and sustainable stewardship of the environment.
Pursuing this vision, the goal of our lab is to understand small biological systems in great detail. We work toward this goal by performing studies that target the fine-tuned synergism between genes, proteins and metabolites, and investigate the resultant, usually very effective functioning of healthy cells and organisms in comparison to those that are mutated or diseased. Milestones along the way are insights into the rationale for the intricate design and operation principles that govern biological systems.
The work in our lab is strictly mathematical and computational, but we collaborate with several superb experimental groups that provide us with data and appreciate our modeling efforts as tools for explanation and hypothesis generation.