"Clinically Informed Biomaterials: Chemistry and Engineering"
Mark Grinstaff, Ph.D.
Distinguished Professor of Translational Research
Professor of Biomedical Engineering, Chemistry, Materials Science and Engineering, and Medicine
As an academic scientist and engineer working in interdisciplinary research, I ask questions all the time – from the most basic (how do we design small molecules to enable the synthesis of advanced materials?) to the most translational (how do we take a laboratory discovery to the clinic?). Through this process, I challenge my students and fellows to determine and elucidate the underlying chemistry and engineering principles. In this lecture, I will share our stories and successes in translating ideas from the laboratory to the preclinical and clinic setting. I begin with synthesis of unique dendrimers and dendritic-based hydrogels as adhesives for wound management, followed by the synthesis and use of polyglycerol carbonates for controlled drug delivery to prevent lung cancer recurrence, and, finally, ROMP to prepare large molecular weight polyanions as lubricants for cartilage surfaces and the potential treatment for osteoarthritis. In each section, I will highlight the design requirements, the synthetic routes and characterization data, and the performance outcomes in in vitro and in vivo experiments.
The Bioengineering Seminar Series is co-hosted by the Parker H. Petit Institute for Bioengineering and Bioscience, and the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University.